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The standard initiation protocol involves starting at 0.25 mg once weekly for four weeks (a non-therapeutic dose intended to improve gastrointestinal tolerability), then increasing to 0.5 mg weekly

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Key takeaways Brand tirzepatide (Mounjaro & Zepbound) is fully FDA-approved, while compounded versions are mostly illegal in 2026

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Type 2 diabetes is an established risk factor for cognitive decline and dementia, with insulin resistance and chronic hyperglycaemia potentially contributing to neuronal damage

Dosing must always be determined and supervised by a licensed medical provider