The PIONEER trial program (Aroda et al
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In healthy fasted individuals, it is recognized that peripheral plasmatic active GLP-1 (7-36) NH2 plasmatic levels hover around 5 pM, but within 510 min after an oral glucose load, they start to rise, up to a maximum of less than 10 pM after 4090 min, and slowly descend back to baseline values in 150 min
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Pollard 2005 J Biomed Mater Res confirmed the acceleration of cutaneous healing in injured animals and humans
One case involved severe electrolyte depletion (sodium and chloride), another resulted from fluid overload, and a third occurred in a patient with pre-existing liver disease who developed septicemia (blood poisoning)