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PLoS One 2015;10:e0118660

Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+) J

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Thus, the binding and automatic blocking of this receptor subtype reduces the activity of protein kinase A (PKA) by decreasing the level of extracellular Ca 2+ that can penetrate inside the cell, thus lowering the amount of Glu released, hence reducing neuroinflammation [87,96]

However, in evolutionary context it makes sense, as Met-derived GSLs are a later invention in plant evolution (both in comparison to other types of GSL and other types of secondary metabolites), and during evolution plants made use of already existing transporters from primary metabolism