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Current strategies for the restoration of cartilage functions include microfracture, mosaicplasty, cartilage transplantation, and medication treatment 5,6,7

Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, et al

The obesity epidemic continues to grow, with nearly 1 billion people worldwide living with this condition, according to the World Health Organization

Compellingly, GCN2 expression in CD4 + T cells is associated with anergy and tolerance to tissue (tumor) damage [151, 152], probably being an interesting molecular target for antagonism, improving antitumor immunity while also restraining tumor cells survival, at least for some tumors

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