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Diabetologia (2001) 44(11):201824

With that said, consider keeping some B12 on hand for your animals

In fact, adenosine acting through microglial A 2A receptors potentiates nitric oxide release [484], and in PD models, A 2A receptor antagonists reduce neuroinflammation by suppressing microglial activation and pro-inflammatory cytokine production, contributing to neuronal survival

They are NOT recommended for individuals with: Ulcerative colitis, Crohns disease, or active GI inflammation Severe hemorrhoids Heart arrhythmias or uncontrolled hypertension Pregnancy Kidney disease (electrolyte shifts can be dangerous) Caffeine sensitivity Always consult a licensed provider if you have chronic conditions or are following a detox program

High-dose B12, given through injections, may help ease these symptoms