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So if experience tells you that caffeine keeps you awake (caffeine blocks the effect of adenosine on the brain - read here about adenosine and sleep) our suggestion is to have your last coffee just after lunch for a better nights sleep (and watch the total amount of caffeine you consume)

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 19802015: a systematic analysis for the Global Burden of Disease Study 2015

Increased endoplasmic reticulum (ER) stress resulting from inappropriate proteostasis machinery has been detected in lung epithelial cells [72]

Understanding the impact of pulmonary rehabilitation on airway resistance in patients with severe COPD: A single-center retrospective study