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Furthermore, compared to normal thyroid tissue, antioxidant catalase expression was significantly reduced in human thyroid tumours (131)

Despite that miss, Biogen says it will advance diranersen to registrational development, pointing to robust reductions in cerebrospinal fluid tau and tau positron emission tomography signals across all studied doses, as well as pre-specified secondary analyses showing slowing of cognitive decline, particularly at the lowest dose of 60mg every 24 weeks

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Together with the already available GIP receptor antagonists it may be possible to clarify further questions that have hitherto remained unanswered

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