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In addition, lipid peroxidation products such as 4-HNE [43], MDA [44], and isoprostanes [45] are widely used as biomarkers of lipid peroxidation

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Serum Pyk2 levels are negatively correlated with iron levels, and targeted inhibition of Pyk2 can alleviate S-ALI in mice, reduce inflammatory responses, and regulate the expression of ferroptosis-related proteins (such as GPX4 and ACSL4) (Wang et al., 2023d)

doi:10.1016/j.chom.2018.12.006 17

Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species