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The standard errors are approximated by the square root of the diagonal elements of the covariance matrix for the estimated parameters \(s^2\) is the approximation of the variance of the data measurement errors, obtained by \(s^2=J_{\text{ min /(m-p)\), where \(J_{\text{ min \) is the minimum of the error function from the parameter estimation 61

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Each escalation step roughly doubles the previous dose until reaching the 1.8 mg level, after which increases become more modest

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