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When liver cells are overwhelmed by free radicals and depleted of glutathione, Phase II detoxification pathways slow down

Intahphuak S, Khonsung P, Panthong A

doi:10 } : CS1 maint: multiple names: authors list (link) "Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance"

Although vitamin B 12 is upstream of GSH in 1-carbon metabolism, the topology depicted in Figure 1 alone is not sufficient to anticipate how changes in will influence GSH