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Furthermore, compared to oral administration, rectal administration can avoid degradation in the digestive system, increase local rectal drug concentrations, and reduce systemic toxic side effects [29,30,31,32,33,34]

This method allows for precise control over drug release timing, which boosts delivery efficiency and reduces side effects [70]

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In addition, the feasibility of using the prepared system as a dropless approach for glaucoma treatment was assessed ex vivo and on glaucoma-induced rabbit model in vivo

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