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Commonly used instruments include Self-Rating Depression Scales, such as the PHQ-9, and clinical assessment scales, such as the HAMD

In our study, co-occurrence network analysis revealed a significant increase in the gut microbiota Bacteroides barnesiae in ESC group, which was strongly positively correlated with key sphingolipid metabolism-related metabolites (such as Sphingosine and Sphingosine-1-phosphate) in the serum, as well as with Sptlc1, a protein associated with sphingolipid metabolism in the hippocampus

Thermal Shift assays Tryptophan fluorescence measurements were carried out using Prometheus Panta (NanoTemper Technologies)

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They also have an impact on NAMPT levels 6 , which fluctuate to meet cellular NAD+ demand

24 weeks ~40 syringes Two injections per week from Week 9 onward