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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Barisic I., Balenovic D., Klicek R., Radic B., Nikitovic B., Drmic D., Udovicic M., Strinic D., Bardak D., Berkopic L., et al

Other mechanisms explaining the effects of metformin on thyroid cell growth and viability are the downregulation of cyclin D1, the increase of the ER stress and the reduction of mRNA levels of AKT, PI3K, and FOXO1 LRP2 and p-JNK, genes that play a crucial role in cell proliferation and survival (Oyadomari and Mori, 2004

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While peptide-based GLP-1 receptor agonists such as Exenatide, Liraglutide, Dulaglutide, and Semaglutide have demonstrated strong efficacy, there remains significant interest in developing next-generation therapies