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I heard someone mention there is some genetic variant which may be at play here

The Growing Obesity Crisis and Treatment Landscape Obesity is a chronic metabolic disease characterized by excessive body fat accumulation and is associated with a higher risk of cardiovascular disease, type 2 diabetes (T2D), and cancer

Wiernicki B, Dubois H, Tyurina YY, Hassannia B, Bayir H, Kagan VE, et al

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For many people, using semaglutide weekly marks the end of cravings, frenzied eating, and constant feelings of hunger

"Further study in the form of prospective trials is needed to better characterize their benefits and risks in this patient population." That RA and metabolic function are interrelated isn't a new suggestion