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Gastrointestinal disorders and surgeries Some GI-related conditions and surgeries may affect B12 absorption: Crohns disease: A chronic inflammatory disease, Crohns affects the small and large intestine particularly the distal ileum, which is where B12 is absorbed

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Participants in the trial who used tirzepatide had better improved A1C, lost more weight, and had less instances of hypoglycemia than those who used fast-acting insulin.