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It promotes angiogenesis (formation of new blood vessels), helps regulate nitric oxide activity, and provides broad protective effects across the gastrointestinal system, muscles, and nervous tissue

However, its distribution and bioavailability are affected by formation of conjugates by methylation, sulfation, and glucuronidation [144, 149]

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Thats compared to the 2.4% reduction experienced in the placebo arm and represents a primary endpoint win