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Intracellular polyunsaturated fatty acids (PUFA) are catalyzed to produce phospholipid-polyunsaturated fatty acids (PL-PUFA), which can be peroxidized either enzymatically or nonenzymatically to form PLOOH ( Since ferroptosis is a result of an imbalance between oxidative and antioxidant oxidation in the cell, intracellular antioxidant factors, such as the GPX4 antioxidant system, are available to protect the cell from ferroptosis

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