To determine which metabolic regulator, AMPK or mTORC1, affect MOTS-c expression levels in Min6 -cell lines, we treated the Min6 cells with mTORC1 activator (MHY1485), its inhibitor (rapamycin) and the AMPK activator (AICAR) and its inhibitor (compound C) (Supplementary Fig
REM (for BNP), 0.27 [0.48, 0.07] %
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Based on these previous studies, we assume that resveratrol could promote the effect of GLP-1 in the intestine and CNS through the activation of diverse genes such as SIRT1 and Foxo genes