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Mouse purchase and housing conditions All animal experiments were performed under the listed procedures detailed in UK Home Office-approved Project Licence PP7597478, and were approved by the University of Cambridge Animal Welfare and Ethics Review Board (AWERB) and adhered to 3Rs and ARRIVE guidelines

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Conclusion This study is limited by the real-world variation for individual treatment costs (e.g

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Ensuring proper timing, dose adjustments, and individual assessment will help reduce potential complications, allowing both treatments to work effectively and safely together