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In particular, GLP-1 treatments require personalized adjustments based on the individuals response, diet, and physical activity level

Among the 14 identified candidates, acetylcarnitine was finally selected by confirming whether it was endogenous in the blood, matched with the mass value, and exhibited a significant difference in intensity between the MDD and control groups (Figure 4)

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Hypotonic patterns are characterized by reduced propulsive activity and blunted postprandial responses, whereas hypertonic patterns are associated with increased non-propulsive segmental contractions and elevated colonic tone ( In this complex umbrella of phenotypes, a step-up approach, starting from shared therapeutic strategies and progressing toward personalized interventions, has been proposed

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