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In the H 2 O 2 -induced melanocyte model, Hyp protected melanocytes from oxidative damage by regulating the PI3K/Akt pathway, inhibiting p38 phosphorylation and suppressing mitochondrial apoptotic signaling, which included upregulation of the Bcl-2/Bax ratio and expression of Akt, and downregulation of caspase 3, p38 (Yang et al., 2016)

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Analytical procedures The plasma homocysteine levels and hepatic cysteine, GSH, cysteinyl-glycine (Cys-Gly) concentrations were measured according to the previous method [21]

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