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A previously published case report from the US also described areas of LGE in a patient with PCD who had been non-compliant with regards to L-carnitine supplementation 23

They measured the apparent levels of messenger RNA (mRNA) associated with urea cycle enzymes in the liver, evaluated the overall nitrogen balance, and hypothesized the nitrogen contents of various organs

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In preclinical studies, CSPG biosynthesis inhibitors were shown to be efficient for rescuing OPC differentiation in vitro and accelerating remyelination in mice (Lau et al., 2012