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Without intervention, approximately 20-30% of weight lost comes from lean tissue rather than fat stores

Converting that hypothesis into knowledge requires PCOS-specific clinical trials with metabolic and reproductive endpoints, adequate duration, and rigorous attention to fertility and pregnancy safety

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Tirzepatide offers dual action by also activating glucose-dependent insulinotropic polypeptide (GIP) receptors, which may contribute to its enhanced weight loss efficacy compared to single-agonist formulations

The Binge Trigger: For many, the 16-hour fast leads to such intense hunger that they overeat during the 8-hour window

It is notable that neither the GLP-1R antagonist exendin(939) nor the GRA REMD2.59 had any (major) effect on glucagon secretion at 1 mmol/l glucose, making it unlikely that glucagon secretion is under significant autocrine control by glucagon or GLP-1(736) [63, 64] from alpha cells