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Cell 126:349359 Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M (2015) Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice

This biopsy-based approach -- using sophisticated single-cell analyses in collaboration with Sandeep Datta, M.D., Ph.D., at Harvard University -- revealed widespread infiltration of T-cells engaged in an inflammatory response in the olfactory epithelium, the tissue in the nose where smell nerve cells are located

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A traditional cigarette could contain, say, 8mg of nicotine, of which the body takes in around 1-2mg

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