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Herms, A., Bosch, M., Reddy, B

doi: 10.1038/ng.3107 6 ClarkeGMRockettKKivinenKHubbartCJeffreysAERowlandsKet al

doi:10.1371/journal.pone.0052572

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These findings suggested that palmatine is highly possible to be a promising leading compound for AD treatment

This apparent discrepancy is not uncommon for this type of compound as similar results have been previously reported for ellagic acid, which displays 100 fold higher potency against parasites than against the purified GST enzyme, with a Ki of 74 M in an enzyme assay but an EC 50 of 0.8 M in antiparasitic assays (Sturm et al., 2009)