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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

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Carrillo-JimenezAPuigdellvolMVilaltaAVeneroJLBrownGCStGeorge-HyslopPet alEffective knockdown of gene expression in primary microglia with siRNA and magnetic nanoparticles without cell death or inflammation

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