Common side effects include nausea, vomiting, diarrhea, constipation, headache, dizziness, and injection site reactions
At 5mg/mL, that same 0.1mg dose would require only 2 units, which is difficult to see on most syringes and increases the risk of measurement error
Conversely, point estimates for tirzepatide showed a potential modest advantage for heart failure endpoints, with CIs compatible with no difference, consistent with recent data supporting protective effects of semaglutide and tirzepatide on heart failure outcomes and a potential incremental benefit with the latter 22
Signs include excessive thirst, dry mouth, dark urine, and dizziness or lightheadedness when standing up
Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial
The manufacturer provides clear guidance based on the timing of the missed dose, which helps maintain therapeutic effectiveness whilst minimising potential side effects