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Dry mouth (a side effect of smoking) worsens the issue by reducing saliva, which normally helps cleanse bacteria and food debris
Data from our previous study also demonstrated that cigarette smoke significantly inhibited EGF synthesis and its mRNA expression in salivary glands and gastric mucosa in rats with acetic acid ulcers (29)
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The etiology of SA is multifactorial, involving genetic abnormalities, structural uterine anomalies, hormonal imbalances, infections, and immunologic dysfunction 4,5
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