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When IGF-1 LR3 binds to the insulin receptor, it activates a complex signaling pathway that triggers protein synthesis, glucose uptake, and amino acid uptake within muscle cells

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To further clarify the contribution of VKOR and FSP1 to vitamin K reduction in a cellular milieu, we examined the carboxylation efficiency of FIXgla-PC/HEK293 reporter cells when their endogenous VKOR (and VKOR-like enzyme, VKORL) or FSP1 was knocked out