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In addition, CS directly affects the epithelial cells and results in increased permeability, mucus overproduction, increased release of proinflammatory cytokines and chemokines, enhanced recruitment of neutrophils, and disturbed lymphocyte balance toward T helper type 2 (Th2) cells (Strzelak et al., 2018)

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Both types require professional treatment for effective removal, but tar stains on teeth tend to respond more readily to scaling and polishing, while nicotine stains on teeth penetrating the enamel require whitening agents to oxidize and break down the embedded pigment