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The following overdose symptoms on wet drugs indicate a medical emergency: Extreme agitation or complete, catatonic unresponsiveness Severely elevated body temperature (hyperthermia) Dangerously high blood pressure or an irregular heartbeat Seizures or uncontrolled convulsions Muscle breakdown (rhabdomyolysis) that can cause acute kidney failure Respiratory depression or stopped breathing Loss of consciousness, stupor, or coma What to Do If Someone Overdoses on Wet Drugs Call 911 immediately and do the following if someone overdoses on wet drugs: Avoid close contact if the person is aggressive or highly agitated Do not attempt to physically restrain the individual Do not offer food or water Speak calmly if the person is conscious Reduce environmental stimulation (avoid loud noise and bright lights) Stay nearby at a safe distance until emergency services arrive Inform responders of any known substance use (e.g., PCP or wet drugs) Understand there is no antidote

This may be associated with increased detoxification induced by physical exercise

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