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SURPASS-3: Body Composition Data A DEXA substudy in SURPASS-3 (N=1,444) quantified that tirzepatide reduced fat mass by approximately 33% more than insulin degludec on a matched weight-loss basis [24]

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Upon examination of mitochondria by electron microscopy, both the 5FU-treated and control groups exhibited comparable mitochondrial structures

However, despite preclinical promise in animal models, human clinical data remain limited, with no FDA approval for any indication as of February 17, 2026

If I knew there were really bad side effects, then maybe I wouldnt do it