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This foundational in vivo evidence has driven an expanding research programme using FOXO4-DRI as a molecular tool across multiple tissues and disease contexts

[DOI] [PMC free article] [PubMed] [Google Scholar] 251.Bohn T., Castenmiller J., de Henauw S., Hirsch-Ernst K.I., Knutsen H.K., Maciuk A., Mangelsdorf I., McArdle H.J., Naska A., Pentieva K., et al

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doi: 10.1021/acs.jmedchem.8b01165 171 BhopaleKKSrinivasanMP

Glutathione is a tri-peptide made from three amino acids: cysteine, glutamate, and glycine

Mood-altering drugs such as SSRIs, benzodiazepines, or antipsychotics do nothing to improve glutathione status, mitochondrial function, or detoxification