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PINK1 enters mitochondria and is quickly broken down

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American Academy of Neurology guidelines on treating painful DPN recommend that clinicians evaluate oral, topical and nonpharmacologic therapies for patients with painful diabetic polyneuropathy, and emphasizes switching between drug classes rather than trying multiple agents within the same class if one fails [63]

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Most patients report that early nausea and digestive changes improve significantly once their body adjusts to the medication