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Exploiting glutamine consumption in atherosclerotic lesions by positron emission tomography tracer (2S,4R)-4-18F-fluoroglutamine

10.1161/CIRCRESAHA.110.223545 21 GiribabuN.KumarK

The injection is given subcutaneously once a week

The de novo biosynthesis of sphingolipids, catalyzed by serine palmitoyltransferase, connects serine and mitochondrial alanine metabolism to membrane lipid diversity, a mechanism that could be exploited to induce tumor cell death under metabolic stress, such as in an amino acid-deprived microenvironment [126]

S., Aboul Ezz, H