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Of the intranasally challenged mice, 20% developed meningitis without bacteremia, and the authors found that the infection induced a decreased expression and a relocation of the junction protein N-cadherin in the olfactory epithelium, which connects the nasopharynx with the CNS

L-Ascorbic acid (Sigma, A4403) was used as a positive control

Additionally, HGF displays pleiotropic functions in a variety of tissues and organs and therapeutic applications of investigational HGF drugs (application of new drugs developed on the basis of these HGF-mediated effects, for clinical therapy) have been tested in various diseases as described before

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People taking certain medications for acid reflux (proton pump inhibitors) or diabetes (metformin) should also monitor their levels closely, as these drugs can interfere with absorption.