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New tobacco customers seeking greater value or shifting retail brands are coming to Murphy USA while existing customers really don't have a better value option to trade down to as targeted promotional activity helps insulate the category, Clyde said

Moreover, smoking-induced CO exposure leads to endothelial dysfunction and increased oxidative stress, accelerating atherosclerosis and vascular damage

Rizzo G, Veronese M, Tonietto M, Zanotti-Fregonara P, Turkheimer FE, Bertoldo A

Moreover, users often inhale even more strongly and deeply, because the filters contribute to the comfort of smoking and reduce lung irritation

The harmful effects of smoking had just started to become public knowledge at that time

And it gets worse: If you have bipolar disorder, near-daily smoking could worsen mania-like symptoms, some research finds, and heavy users may also have more thoughts of suicide more often than non-users, another study indicated