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Microdosing GLP-1 medications lacks clinical evidence, meaning doctors dont have enough reliable data to confirm whether lower than approved doses are effective

#DDW2025 OBESITY AND IBD by @EdwardLoftus2 Obesity is a chronic inflammatory statue Adipose tissue is not biologically inert (TNFa, IL-6, IL-8, leptin, adiponectin) Postulated role in the pathogenesis of IBD Potential risk factor for adverse outcomes Trends in BMI among IBD patients at diagnosis in Olmsted County, Doubling of obesity rates in 20 years in CD and UC (Johnson AM JCC 2021 and J Clin Gastro 2024) Obese patients more likely to have a colonic phenotype

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Stable eating patterns, normal bowel function, and absence of persistent abdominal discomfort suggest adequate adaptation to the current dose

PT-141 (Bremelanotide) is a peptide therapy that may enhance sexual arousal and libido by activating melanocortin receptors in the brain

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