When either of two proteins, NPC1 or NPC2, is not functional, it leads to impaired cellular trafficking of endocytosed LDL cholesterol and its accumulation in the lysosomes
However, there are many factors that affect timing, and sometimes progress depends on the eye of the beholder
References 1 BuchanAMJPolakJMCapellaCSolciaEPearseAGE
( a, e, j ) Gold-standard Fourier Shell Correlation (FSC) curves for the consensus map (a), conformer 1 (e), and conformer 2 (j) showing overall nominal resolutions of 2.3 , 2.4 , and 2.5 , respectively
optional MIC (Lipo-C) or carnitine when appropriate
This sort of thing of aligning four labs along a common theme, a common goal, bringing in multiple techniques, multiple lines of expertise and really making what I think are significant strides towards an important biological and clinical problem that could have only happened with this kind of CFC initiative