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Particularly, in Pseudomonas spp ., nicotine is metabolized to produce 6-hydroxy-3-succinyl pyridine, which can be used in the synthesis of the insecticide imidacloprid and antiparkinsonian agents, as well as 2,5-dihydroxypyridine, which can be used in the synthesis of plant growth hormones and vitamin B12 [91]

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These are both methods of direct cooking

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Additionally, studies indicate that long-term alcohol use can contribute to leukoplakia