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A major concern of drug use is overdose, which can cause a lowered heart rate, shallow breathing, loss of consciousness, seizures, stroke, coma, and even death

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Duke, Sons and Company's brand Duke of Durham lagged behind that of Bull Durham

Meadows and Wilson, 2021)

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Twin studies [3] and heritability estimation based on genome-wide association studies (GWASs) [4, 5] indicated that genetic factors contribute far less to incident lung cancer than environmental factors, including smoking