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It is a synthetic cyclic octapeptide a ring of eight amino acids that binds directly to the MC4R with an inhibitory constant of 2.1 nM and an effective concentration of 0.27 nM, making it substantially more potent and selective than the endogenous hormone it replaces

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10.1016/j.biopha.2022.113059 215 WanX.GuoH.LiangY.ZhouC.LiuZ.LiK.et al (2020)

Asymmetric dimethylarginine (ADMA) accumulates in the plasma of CKD patients, potentially decreasing endothelial NO production