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Weight-bearing exercise (walking, jogging or any exercise done on the feet) and strength training for muscles can help fortify bones and build bone mass

Patients should contact their provider if leg cramps are severe, persistent, or accompanied by swelling, weakness, or dark urinesymptoms suggesting rhabdomyolysis or serious muscle injury

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The divergence in the effect of mutagenesis of residues comprising the TM-binding pocket, even where interactions in the static consensus structures were similar, confirmed that static visualisation of complexes is insufficient to fully understand binding and activation mechanisms, and suggests that the dynamics of peptide-receptor engagement likely play a critical role

The strength of the signal was also found to differ markedly between formulations