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Ketamine is currently the best-studied hallucinogen in the field of sustained antidepressant effect [17,18,19,20], and with psilocybin being granted breakthrough therapy for the treatment of depression by the U.S
When stress increases cortisol, it has the ability to blunt GnRH pulses, but peptide signals can restore pulse frequency and amplitude, which supports appropriate FSH and LH release
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Lip-1 exerts its effects by disrupting iron ion metabolism, mitigating lipid peroxidation-induced cellular damage, and demonstrating neuroprotective properties in cellular models ( -Tocopherol, also known as vitamin E, is a potent natural antioxidant that also functions as a ferroptosis inhibitor, effectively attenuating cellular lipid peroxidation and inhibiting ferroptosis ( Despite their potent anti-ferroptotic effects, these inhibitors face significant challenges in clinical translation, primarily due to pharmacokinetic and physicochemical limitations
Good sources include fish, beef, eggs, milk, and yogurt
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