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Specifically, individuals exposed to in utero tobacco who were early-onset smokers had the highest risk of COPD incidence, with an HR (95% CI) of 3.92 (3.54, 4.31), compared with non-smokers without in utero tobacco exposure

35 In addition, E-cigs have been reported to suppress cellular antioxidant defenses, which results in significant DNA damage in pulmonary epithelial cells

Data from national Youth Risk Behavior Surveys (YRBS) show that while current use of combustible tobacco products (cigarettes and cigars) dropped dramatically from 2001 to 2013 among all high school students (31.5 percent to 19.5 percent), current use of smokeless tobacco remained unchanged among non-athletes (5.9 percent) and increased among athletes (10 percent to 11.1 percent)

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