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Psoralens and ultraviolet A (PUVA) phototherapy

Long-term (months to years), the freezer at -20 degrees Celsius preserves potency best

It should not be expected to reverse severe osteoarthritis, regrow advanced cartilage loss, correct major joint deformity, heal a complete tendon rupture without appropriate orthopedic management, or replace surgery when surgery is clearly indicated

doi: 10.1016/S2213-8587(15)00482-9

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These numbers are unprecedented for a non-surgical, pharmacological intervention and notably the weight-loss curve had not fully plateaued at 48 weeks, suggesting that even greater reductions might occur with longer exposure