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Because it contains 0.9% benzyl alcohol, it lasts longer than sterile water once opened but proper storage is still essential

ImerslundGrasbeck syndrome in a Chinese family with distinct skin lesions refractory to vitamin B12

Excess hydroxocobalamin can bind to other plasma proteins such as albumin, which helps explain the very high B12 levels seen after injections of that form

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However, if it improves your adherence and tolerability, the theoretical pharmacokinetic disadvantage may not matter practically

Gastric and intestinal protection is the second major research stream, consistent with the compound's gastric-juice origin