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Patients on any oral antihyperglycemic agent in monotherapy (N=212) or on a PPAR agent in combination therapy (N=106) or not on an antihyperglycemic agent (off therapy for at least 8 weeks, N=34) were switched to monotherapy with pioglitazone (at a dose of 30-45 mg per day), and completed a run-in period of approximately 12 weeks in duration

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For example, in one study of cats with severe cobalamin deficiency and chronic GI conditions, regular B12 injections led to normalisation of methylmalonic acid levels (a marker of B12 status) and was associated with clinical improvement [25]

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Cancer pain Gong et al