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The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx

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This effect is believed to occur through PYY(136) binding to Y1 receptors in the hypothalamus, which activates NPY/AgRP neurons, increases NPY expression in the ARC, and indirectly inhibits pro-opiomelanocortin/Cocaine amphetamine regulated transcript (POMC/CART) neurons [47, 49]

This includes COL1A1 and COL1A2 (coding for Collagen Type I), COL3A1 (Collagen Type III), and ELN (Elastin)