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If lesions significantly decreased in size (more than 20% in diameter) on follow-up (either by CT or plain chest radiographs) or were stable for 2 years without treatment, PTNB procedures were defined as true-negatives [10]

The authors did highlight some limitations of the study: Behaviors were self-reported, which could lead to reporting errors, and some factors affecting dementia, such as medications, diet, and sleep, were not measured

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The statute directs the Agency to consider how a product will be used by consumers as actually used, including effects on initiation, cessation, and switching behavior at the population level

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